| Date | Home | Away | Result |
|---|---|---|---|
| 11/12/25 17:45 | Fiorentina | Dynamo Kiew | 2-1 |
| 11/12/25 17:45 | Jagiellonia Bialystok | Rayo Vallecano | 1-2 |
| 11/12/25 17:45 | KF Drita Gjilan | AZ Alkmaar | 0-3 |
| 11/12/25 17:45 | Breidablik Kopavogur | Shamrock Rovers | 3-1 |
| 11/12/25 17:45 | Samsunspor | AEK Athens | 1-2 |
| 11/12/25 17:45 | KF Shkendija | SK Slovan Bratislava | 2-0 |
| 11/12/25 17:45 | BK Häcken | AEK Larnaka | 1-1 |
| 11/12/25 17:45 | Universitatea Craiova | Sparta Prag | 1-2 |
| 11/12/25 17:45 | FC Noah | Legia Warschau | 2-1 |
| 11/12/25 20:00 | SK Rapid Wien | Omonia Nicosia | 0-1 |
| 11/12/25 20:00 | Lech Poznan | FSV Mainz 05 | 1-1 |
| 11/12/25 20:00 | HNK Rijeka | NK Celje | 3-0 |
| 11/12/25 20:00 | Lincoln Red Imps FC | Sigma Olomouc | 2-1 |
| 11/12/25 20:00 | Kuopion PS | FC Lausanne-Sport | 0-0 |
| 11/12/25 20:00 | FC Aberdeen | Racing Club Strasbourg | 0-1 |
| 11/12/25 20:00 | KS Rakow Czestochowa | HŠK Zrinjski Mostar | 1-0 |
| 11/12/25 20:00 | Hamrun Spartans | Schachtjor Donezk | 0-2 |
| 11/12/25 20:00 | FC Shelbourne | Crystal Palace | 0-3 |